Introduction: Coinfection with Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) is a global public health problem, particularly in high-endemicity regions like sub-Saharan Africa. This coinfection is associated with an accelerated progression of liver disease and a worse prognosis.

Objective: To evaluate morbidity and mortality in patients treated at Hospital Américo Boavida in Angola with HIV/HBV coinfection (2010-2012).

Methods: A retrospective descriptive study was conducted in the Infectious and Parasitic Diseases Service (SDIP) of Hospital Américo Boavida between 2010 and 2012. Out of a total of 2397 hospitalized patients,rn237 (9.9 %) with confirmed positive serology for both viruses constituted the sample. Sociodemographic, clinical, laboratory, and treatment data were collected from medical records.

Results: The coinfection prevalence was 9.9%. The median age was 26-35 years (38%), with a predominance of females (62%). The most common risk factor was heterosexuality (40.1%). Most patients presented with WHO clinical stage IV (42.2%) with CD4 counts <200 cells/mm3 (28.3%). Tuberculosis was the most frequent opportunistic infection (35%). The most used antiretroviral regimen was AZT+3TC+NVP (21.6%). The in-hospital mortality rate was 33.8%.

Conclusion: HIV/HBV coinfection represents a significant proportion of hospital admissions in this context. The high mortality observed underscores late presentation, the high frequency of severe immunosuppression and tuberculosis, and limitations in the complete diagnosis of HBV. Strategies for early diagnosis and comprehensive management of this population are needed.